Keywords

• Reliable quality 520-18-3
• 520-18-3 good supplier
• Kaempferol global trader

Quick Details

• ProName: Reliable quality 520-18-3 good supplie...
• CasNo: 520-18-3
• Molecular Formula: C15H10O6
• Appearance: Yellow powder
• Application: kaempferol has anti-cancer, anti-ferti...
• DeliveryTime: Stocks
• PackAge: according to customers' requirements
• Port: Any port
• ProductionCapacity: 100 Metric Ton/Day
• Purity: 98%
• Storage: 2-8°C
• Transportation: By air(EMS or EUB or FedEx or TNT ect....
• LimitNum: 1 Gram

Superiority

Reliable quality 520-18-3 good supplier Kaempferol global trader

kaempferol has antioxidant, anti-inflammatory, anti-cancer, prevention and treatment of diabetes, atherosclerosis and osteoporosis, as well as protection of nerve, liver and myocardium, inhibition of protein kinase and other nutritional and health effects. As a health food and medicine, kaempferol has a very broad market.

1) hydrolysis to prepare hydroxyacetophenone intermediate 1.1) put 30g of dihydromyricetin with a content of more than 98% into the reactor, then add 400g of sodium hydroxide solution with a mass fraction of 15%, stir and mix evenly, raise the temperature and reflux, and carry out hydrolysis reaction; High performance liquid chromatography monitoring, with the hydroxyacetophenone intermediate no longer increasing as the reaction control end point, after 2 hours, stop the reaction. Cooling to 30 ℃, slowly dropping 50% hydrochloric acid solution into the reaction solution, adjusting pH to about 6.2, stirring for 2 hours, standing for 1 hour, filtering to obtain light yellow viscous solid. 1.2) 150g of 95% ethanol is added to the light yellow viscous solid obtained in step 1.1), heated and refluxed for 1h, then filtered to obtain a solid while hot, then 90g of 95% ethanol is added to the solid, heated and refluxed for 1h again, beaten to room temperature, let stand for 2h, then filtered and dried to obtain a light yellow solid, I .e. hydroxyacetophenone intermediate (2-hydroxy -1-(2,4, 6-trihydroxyphenyl) acetyl) 17.8g. 2) Catalytic closed-loop preparation of crude dihydrokaempferol 2.1) Put 17.8g of hydroxyacetophenone intermediate obtained by the reaction in step 1.2) into the reaction bottle, add DMF92g, and stir to completely dissolve the hydroxyacetophenone intermediate. 2.2) Add 3.55g of proline to the solution in step 2.1), raise the temperature to 65 ℃ and keep the temperature unchanged, dissolve 13.9g of p-hydroxybenzaldehyde with 20gDMF and slowly drop it into the reaction bottle for about 2 hours. After dropping, the temperature was raised to 70 ℃ for heat preservation, and the catalytic closed-loop reaction was carried out. High performance liquid chromatography monitoring was carried out. The dihydrokaempferol intermediate was no longer increased as the reaction control end point, and the reaction ended after about 7 hours. 2.3) The solution obtained in step 2.2) is reduced to room temperature, 350g of 5% glacial acetic acid solution is added, stirred for 2 hours, and solid is slowly precipitated. Filter, wash the filter cake with water until neutral and dry to obtain 27.6g of crude dihydrokaempferol. 3) Oxidation Preparation of kaempferol 27.6g of crude dihydrokaempferol obtained in step 2.3) is put into a reaction bottle, 275ml of 65% ethanol is added, stirred evenly, 6g of anhydrous potassium carbonate is added, oxygen is introduced, then the temperature is raised and refluxed, the oxidation reaction is carried out, high performance liquid chromatography monitoring is carried out, the reaction control endpoint is no longer increased with kaempferol, and the reaction is over after about 8 hours. Drop to room temperature and leave overnight, filter to obtain yellow solid, add 200g of water, filter after reflux for 2h, wash and dry the filter cake to obtain 22.3g of kaempferol with 98% content (HPLC).

Details

Established in 2010, located in Hangzhou Qinglan science park, lingruichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals tovarious industries.n our R&D centre. we have a staff of skilled and experienced research chemists. This has enabled us to meet the special reauirements of our customers and it has enabled us to provide quality products at competitive prices.

1. How can we guarantee quality

Always a pre-production sample before mass production;

Always final Inspection before shipment; 

2.What can you buy from us

Plant Extracts,Cosmetics Raw Materials,Vitamin Raw Materials,Pharmaceutical Raw Materials and Intermediates

3. Why should you buy from us not from other suppliers

Our company mainly devoted in producing pharmacetical intermediates , Vitamins , and health supplement , the quality and technical content can reach the advance level in China .Our products are sold well in China as well as in more than 20 countries.

Lingrui's credo is committed to your reliable business partner,reliable quality, competitive prices and superior service, lf you are interested in any of our products or would like to discuss a custom order, please feel free to contact us. We are looking forward to forming successful business relationships with new clients around the world in the near future !