Keywords

• Hot Sale 474-25-9
• 474-25-9 in bulk supply
• best quality 474-25-9

Quick Details

• ProName: Hot Sale 474-25-9 best quality Chenode...
• CasNo: 474-25-9
• Molecular Formula: C24H40O4
• Appearance: White powder
• Application: dissolving gallstone drugs. It is used...
• DeliveryTime: Stocks
• PackAge: according to customers' requirements
• Port: Any port
• ProductionCapacity: 100 Metric Ton/Day
• Purity: 98%
• Storage: room temp
• Transportation: By air(EMS or EUB or FedEx or TNT ect....
• LimitNum: 1 Gram

Superiority

Hot Sale 474-25-9 best quality Chenodeoxycholic acid in bulk supply

Chenodeoxycholic acid is a hydrophobic primary bile acid capable of activating the nuclear receptor FXR, which is involved in cholesterol metabolism.This strain was extracted from the bile of chicken, duck, goose, etc. It is synthesized by cholesterol in the liver and is a free bile acid component in normal bile. Bile contains cholic acid and Chenodeoxycholic acid 30% ~ 40%, deoxycholic acid 10% ~ 20%, lithocholic acid and ursodeoxycholic acid less than 5%, in addition, there are lecithin, cholesterol and bilirubin and other excreta. It can reduce the synthesis and secretion of cholesterol, reduce the total cholesterol excretion of bile, improve the dissolving power of bile to cholesterol, and promote the dissociation of cholesterol from stones to achieve the effect of dissolving stones.

Chenodeoxycolic Acid is a hydrophobic primary bile Acid capable of activating the nuclear receptor FXR, which is involved in cholesterol metabolism. Both Chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA) inhibited 11 beta HSD2 with IC50 values of 22mm and 38mm, respectively, and caused cortisol-dependent nuclear translocation and increased mineralocorticoid receptor (MR). The transcriptional activity. Chenodeoxycholic acid can stimulate the growth of Ishikawa cells by activating the membrane G protein coupled receptor (TGR5)-dependent pathway, inducing a significant increase in the expression of cyclin d1 protein and mRNA. Chenodeoxycholic acid (CDCA) induces approximately 4-fold low-density lipoprotein receptor mRNA levels and 2-fold high-density lipoprotein-CoA reductase and high-density lipoprotein-CoA synthetase mRNA levels in the cultured human hepatoblastoma cell line hepg2. Chlorodeoxycholic acid-induced ISC(≥ 67%) was cftrinh-172 inhibited by bumetanide, Bacl2, and cystic fibrosis transmembrane conductance regulator (CFTR) inhibitors. The adenylate cyclase inhibitor MDL12330A reduces by 43% the Chenodeoxycholic acid-stimulated ISC, which increases the intracellular cAMP concentration. Chenodeoxycholic acid treatment activates c/ebp as shown by its increased phosphorylation, nuclear accumulation and expression in hepg2 cells. Chenodeoxyolic acid enhances the transcription of the luciferase gene in constructs containing the -1.65-kb GSTA2 promoter, which contains the C / EBP response element (pGL-1651). Chenodeoxycholic acid treatment activates AMP-activated protein kinase (AMPK), leading to activation of extracellular signal-regulated kinase 1/2(ERK1/2), experimental results demonstrate the use of dominant negative mutants and chemical inhibitors of ampkα.

Details

Established in 2010, located in Hangzhou Qinglan science park, lingruichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals tovarious industries.n our R&D centre. we have a staff of skilled and experienced research chemists. This has enabled us to meet the special reauirements of our customers and it has enabled us to provide quality products at competitive prices.

1. How can we guarantee quality

Always a pre-production sample before mass production;

Always final Inspection before shipment; 

2.What can you buy from us

Plant Extracts,Cosmetics Raw Materials,Vitamin Raw Materials,Pharmaceutical Raw Materials and Intermediates

3. Why should you buy from us not from other suppliers

Our company mainly devoted in producing pharmacetical intermediates , Vitamins , and health supplement , the quality and technical content can reach the advance level in China .Our products are sold well in China as well as in more than 20 countries.

Lingrui's credo is committed to your reliable business partner,reliable quality, competitive prices and superior service, lf you are interested in any of our products or would like to discuss a custom order, please feel free to contact us. We are looking forward to forming successful business relationships with new clients around the world in the near future !