Keywords

• Supply 159635-49-1
• 159635-49-1 global trader
• 159635-49-1 factory

Quick Details

• ProName: Supply 159635-49-1 global trader 1-Boc...
• CasNo: 159635-49-1
• Molecular Formula: C11H19NO2
• Application: N-Boc-4-methylene piperidine is a chem...
• DeliveryTime: Stocks
• PackAge: according to customers' requirements
• Port: Any port
• ProductionCapacity: 100 Metric Ton/Day
• Purity: 98%
• Storage: under inert gas (nitrogen or Argon) at...
• Transportation: By air(EMS or EUB or FedEx or TNT ect....
• LimitNum: 1 Gram

Superiority

Supply 159635-49-1 global trader 1-Boc-4-methylenepiperidine factory

N-Boc-4-methylene piperidine is an important intermediate containing piperidine ring in drug research and development, especially in the field of anti-cancer drug research and development. As a characteristic fragment, N-Boc-4-methylene piperidine is also widely used as an intermediate in the synthesis of ibrutinib and paliperidone drugs. In industry, it can also be used as a modifier, dye aid, and the starting material for the synthesis of a series of products (including medicines, disinfectants, dyes, food seasonings, adhesives, explosives, etc.). It can also be used as a catalyst, but the amount should not be too much, otherwise the product quality will be affected.

4-methylenepiperidine-1-carboxylic acid tert-butyl ester is added to the suspension of methyl triphenylphosphonium bromide (36.3g,101.6mmol,1.35 equivalent) in ether (dry, 300mL) Potassium tert-butoxide (1) is added under a nitrogen balloon, 1g,98mmol,1.3 equivalent at a time at 0 ℃). The mixture was then stirred under reflux for 2 hours. The hot reaction mixture was cooled to 0°C with an external ice bath, and then a solution of ethyl ether (60mL) of 4-oxo-piperidin-1-carboxylate (15g,75.3mmol,1.0 equivalent) was added dropwise.

. Warm the mixture to room temperature and stir at room temperature for 1 hour. The mixture was then stirred under reflux overnight (16 hours). The mixture was cooled to room temperature and hexane (300mL) was added. Stir the mixture for 10 minutes, filter and elute with hexane/
EtOAc(100/100mL). The combined organic solution was concentrated to obtain the residue, which was purified by CombiFlash(100g silica gel column, EtOAc /
Hex = 0-30%) to obtain 14g (yield 94%)N-Boc-4-methylene piperidine, which is a colorless oil. 1HNMR(400MHz,CDCl
3):δ4.74(s,2H),3.42(t,4H),2.18(t,4H),1.47(s,9H).

Details

Established in 2010, located in Hangzhou Qinglan science park, lingruichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals tovarious industries.n our R&D centre. we have a staff of skilled and experienced research chemists. This has enabled us to meet the special reauirements of our customers and it has enabled us to provide quality products at competitive prices.

1. How can we guarantee quality

Always a pre-production sample before mass production;

Always final Inspection before shipment; 

2.What can you buy from us

Plant Extracts,Cosmetics Raw Materials,Vitamin Raw Materials,Pharmaceutical Raw Materials and Intermediates

3. Why should you buy from us not from other suppliers

Our company mainly devoted in producing pharmacetical intermediates , Vitamins , and health supplement , the quality and technical content can reach the advance level in China .Our products are sold well in China as well as in more than 20 countries.

Lingrui's credo is committed to your reliable business partner,reliable quality, competitive prices and superior service, lf you are interested in any of our products or would like to discuss a custom order, please feel free to contact us. We are looking forward to forming successful business relationships with new clients around the world in the near future !